Browsing by Author "Chifiriuc, Mariana Carmen"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Common themes in antimicrobial and anticancer drug resistance(Frontiers Media, 2022-08-08) Chifiriuc, Mariana Carmen; Filip, Roxana; Constantin, Marian; Gratiela Gradisteanu Pircalabioru, Gratiela Gradisteanu; Bleotu, Coralia; Burlibasa, Liliana; Ionica, Elena; Corcionivoschi, Nicolae; Mihaescu, GrigoreAntimicrobial and anticancer drug resistance represent two of the main global challenges for the public health, requiring immediate practical solutions. In line with this, we need a better understanding of the origins of drug resistance in prokaryotic and eukaryotic cells and the evolutionary processes leading to the occurrence of adaptive phenotypes in response to the selective pressure of therapeutic agents. The purpose of this paper is to present some of the analogies between the antimicrobial and anticancer drug resistance. Antimicrobial and anticancer drugs share common targets and mechanisms of action as well as similar mechanisms of resistance (e.g., increased drug efflux, drug inactivation, target alteration, persister cells’ selection, protection of bacterial communities/malignant tissue by an extracellular matrix, etc.). Both individual and collective stress responses triggered by the chemotherapeutic agent involving complex intercellular communication processes, as well as with the surrounding microenvironment, will be considered. The common themes in antimicrobial and anticancer drug resistance recommend the utility of bacterial experimental models for unraveling the mechanisms that facilitate the evolution and adaptation of malignant cells to antineoplastic drugs.Item Microbiome and cancer: from mechanistic implications in disease progression and treatment to development of novel antitumoral strategies(Frontiers Media, 2024-04-23) Constantin, Marian; Chifiriuc, Mariana Carmen; Mihaescu, Grigore; Corcionivoschi, Nicolae; Burlibasa, Liliana; Bleotu, Coralia; Tudorache, Sorin; Mitache, Magda Mihaela; Filip, Roxana; Munteanu, Simona-Gloria; Gradisteanu Pircalabioru, Gratiela; Animal Health and WelfareCancer is a very aggressive disease and one of mankind’s most important health problems, causing numerous deaths each year. Its etiology is complex, including genetic, gender-related, infectious diseases, dysbiosis, immunological imbalances, lifestyle, including dietary factors, pollution etc. Cancer patients also become immunosuppressed, frequently as side effects of chemotherapy and radiotherapy, and prone to infections, which further promote the proliferation of tumor cells. In recent decades, the role and importance of the microbiota in cancer has become a hot spot in human biology research, bringing together oncology and human microbiology. In addition to their roles in the etiology of different cancers, microorganisms interact with tumor cells and may be involved in modulating their response to treatment and in the toxicity of anti-tumor therapies. In this review, we present an update on the roles of microbiota in cancer with a focus on interference with anticancer treatments and anticancer potential.