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The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3

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dc.contributor.author Lagan Tregaskis, Paula
dc.contributor.author Devaney, Ryan
dc.contributor.author Smyth, Victoria
dc.date.accessioned 2021-02-16T14:37:04Z
dc.date.available 2021-02-16T14:37:04Z
dc.date.issued 2021-02-03
dc.identifier http://hdl.handle.net/20.500.12518/213
dc.identifier.citation Lagan Tregaskis, P., Devaney, R. and Smyth, V. J. (2021) ‘The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3’, Viruses. MDPI AG, 13(2), p. 235. doi: 10.3390/v13020235. en_US
dc.identifier.issn 1999-4915
dc.identifier.uri https://doi.org/10.3390/v13020235
dc.description Publication history: Accepted - 27 January 2021; Published - 3 February 2021. en_US
dc.description.abstract Avian nephritis virus (ANV) is classified in the Avastroviridae family with disease associations with nephritis, uneven flock growth and runting stunting syndrome (RSS) in chicken and turkey flocks, and other avian species. The whole genome of ANV genotype 3 (ANV-3) of 6959 nucleotides including the untranslated 5’ and 3’ regions and polyadenylated tail was detected in a metagenomic virome investigation of RSS-affected chicken broiler flocks. This report characterises the ANV-3 genome, identifying partially overlapping open reading frames (ORFs), ORF1a and ORF1b, and an opposing secondary pseudoknot prior to a ribosomal frameshift stemloop structure, with a separate ORF2, whilst observing conserved astrovirus motifs. Phylogenetic analysis of the Avastroviridae whole genome and ORF2 capsid polyprotein classified the first complete whole genome of ANV-3 within Avastroviridae genogroup 2. en_US
dc.description.sponsorship This research was partially funded by the Department of Agriculture, Environment & Rural Affairs—Code PG 13/02, and the Agri-Food and Biosciences Institute (AFBI)—Code 44955. en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). en_US
dc.subject avian nephritis virus en_US
dc.subject astrovirus en_US
dc.subject phylogenetics en_US
dc.subject molecular characterisation en_US
dc.subject genotyping and recombination en_US
dc.title The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3 en_US
dc.type Article en_US


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