Meta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK andIreland
Date
2017-03-06
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accu-rate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was,through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 differ-ent ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic reviewof the scientific literature (published 1934–2009) diagnostic Se and Sp were estimated using Bayesianlogistic regression models adjusting for confounding factors. Random effect terms were used to accountfor unexplained heterogeneity. Parameters in the models were implemented using Markov Chain MonteCarlo (MCMC), and posterior distributions for the diagnostic parameters with adjustment for covariates(confounding factors) were obtained using the inverse logit function. Estimates for Se and/or Sp of thetuberculin skin tests and the IFN- blood test were compared with estimates published 2010–2015.Median Se for the single intradermal comparative cervical tuberculin skin (SICCT) test (standard inter-pretation) was 0.50 and Bayesian credible intervals (CrI) were wide (95% CrI 0.26, 0.78). Median Sp forthe SICCT test was 1.00 (95% CrI 0.99, 1.00). Estimates for the IFN- blood test Bovine Purified ProteinDerivative (PPD)-Avian PPD and Early Secreted Antigen target 6 and Culture Filtrate Protein 10 (ESAT-6/CFP10) ESAT6/CFP10 were 0.67 (95% CrI 0.49, 0.82) and 0.78 (95% CrI 0.60, 0.90) respectively for Se,and 0.98 (95% CrI 0.96, 0.99) and 0.99 (95% CrI 0.99, 1.00) for Sp. The study provides an overview of theaccuracy of a range of contemporary diagnostic tests for bTB in cattle. Better understanding of diagnostictest performance is essential for the design of effective control strategies and their evaluation.
Description
Publication history: Accepted - 26 February 2017; Published online - 6th March 2017.
item.page.type
Article
item.page.format
Keywords
Bovine tuberculosis, Diagnostic tests, Meta-analysis, Performance, Sensitivity, Specificity
Citation
Nuñez-Garcia, J., Downs, S. H., Parry, J. E., Abernethy, D. A., Broughan, J. M., Cameron, A. R., Cook, A. J., de la Rua-Domenech, R., Goodchild, A. V., Gunn, J., More, S. J., Rhodes, S., Rolfe, S., Sharp, M., Upton, P. A., Vordermeier, H. M., Watson, E., Welsh, M., Whelan, A. O., Woolliams, J. A., Clifton-Hadley, R. S. and Greiner, M. (2018) ‘Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland’, Preventive Veterinary Medicine, 153, pp. 94–107. doi: 10.1016/j.prevetmed.2017.02.017.