Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry
Date
2018-06-19
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Publisher
Elsevier
Abstract
Campylobacter jejuni is the leading cause of food-borne bacterial enteritis in humans, with contaminated poultry
products considered the main source of infection. To survive the food chain, C. jejuni utilizes multiple defense
mechanisms that counter oxidative and aerobic stresses. In this study, we phenotypically characterised 63 C.
jejuni strains with oxidative stress survival and antimicrobial susceptibility testing to investigate correlations
between these two phenotypes against the source of the strains and the presence of the MarR regulators RrpA
and RrpB which have a role in regulating the response to oxidative and aerobic stress. C. jejuni strains isolated
from meat and neck skin displayed the highest resistance to oxidative stress. In addition, C. jejuni strains that
have an rrpA+rrpB− profile exhibit increased resistance to oxidative stress and to antimicrobials. Here we establish
a preliminary link between the distribution of RrpA and RrpB and the increased resistance to antimicrobials.
This study provides insight into how the genotypic make up of C. jejuni can influence the ability of
the bacterium to survive within areas of high oxygen stress, such as the food chain, and subsequently can have a
potential negative impact on human health.
Description
Publication history: Accepted - 13 June 2018; Published online - 19 June 2018.
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Keywords
Campylobacter jejuni, Oxidative stress, Antimicrobial resistance, MarR domain
Citation
Ugarte-Ruiz, M., Domínguez, L., Corcionivoschi, N., Wren, B.W., Dorrell, N. and Gundogdu, O. (2018) ‘Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry’, Research in Veterinary Science. Elsevier BV. doi:10.1016/j.rvsc.2018.06.016