DSpace Repository

Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry

Show simple item record

dc.contributor.author Ugarte-Ruiz, Maria
dc.contributor.author Domínguez, Lucas
dc.contributor.author Corcionivoschi, Nicolae
dc.contributor.author Wren, Brendan W.
dc.contributor.author Dorrell, Nick
dc.contributor.author Gundogdu, Ozan
dc.date.accessioned 2021-06-24T08:40:37Z
dc.date.available 2021-06-24T08:40:37Z
dc.date.issued 2018-06-19
dc.identifier http://hdl.handle.net/20.500.12518/301
dc.identifier.citation Ugarte-Ruiz, M., Domínguez, L., Corcionivoschi, N., Wren, B. W., Dorrell, N. and Gundogdu, O. (2018) ‘Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry’, Research in Veterinary Science, 119, pp. 170–175. doi: 10.1016/j.rvsc.2018.06.016. en_US
dc.identifier.issn 0034-5288
dc.identifier.uri https://doi.org/10.1016/j.rvsc.2018.06.016
dc.description Publication history: Accepted - 13 June 2018; Published online - 19 June 2018. en_US
dc.description.abstract Campylobacter jejuni is the leading cause of food-borne bacterial enteritis in humans, with contaminated poultry products considered the main source of infection. To survive the food chain, C. jejuni utilizes multiple defense mechanisms that counter oxidative and aerobic stresses. In this study, we phenotypically characterised 63 C. jejuni strains with oxidative stress survival and antimicrobial susceptibility testing to investigate correlations between these two phenotypes against the source of the strains and the presence of the MarR regulators RrpA and RrpB which have a role in regulating the response to oxidative and aerobic stress. C. jejuni strains isolated from meat and neck skin displayed the highest resistance to oxidative stress. In addition, C. jejuni strains that have an rrpA+rrpB− profile exhibit increased resistance to oxidative stress and to antimicrobials. Here we establish a preliminary link between the distribution of RrpA and RrpB and the increased resistance to antimicrobials. This study provides insight into how the genotypic make up of C. jejuni can influence the ability of the bacterium to survive within areas of high oxygen stress, such as the food chain, and subsequently can have a potential negative impact on human health. en_US
dc.description.sponsorship This work was partially supported by the Ministry of Science and Innovation (AGL2009-07550; AGL2012-39028) and by the Autonomous Community of Madrid, Spain (S2009/AGR-1489; S2013/ ABI-2747). M. Ugarte-Ruiz was supported by the FPU programme (AP2009- 1747) from the Spanish Ministry of Education, Culture and Sports during her stage at London School of Hygiene & Tropical Medicine (2013). en_US
dc.language.iso en en_US
dc.publisher Elsevier en_US
dc.rights © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/). en_US
dc.subject Campylobacter jejuni en_US
dc.subject Oxidative stress en_US
dc.subject Antimicrobial resistance en_US
dc.subject MarR domain en_US
dc.title Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account