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Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism

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dc.contributor.author Reyer, Henry
dc.contributor.author Oster, Michael
dc.contributor.author Magowan, Elizabeth
dc.contributor.author Dannenberger, Dirk
dc.contributor.author Ponsuksili, Siriluck
dc.contributor.author Wimmers, Klaus
dc.date.accessioned 2021-07-16T13:39:57Z
dc.date.available 2021-07-16T13:39:57Z
dc.date.issued 2017-08-01
dc.identifier http://hdl.handle.net/20.500.12518/320
dc.identifier.citation Reyer, H., Oster, M., Magowan, E., Dannenberger, D., Ponsuksili, S. and Wimmers, K. (2017) ‘Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism’, International Journal of Molecular Sciences, 18(8), p. 1674. doi: 10.3390/ijms18081674. en_US
dc.identifier.issn 1661-6596
dc.identifier.issn 1422-0067
dc.identifier.uri https://doi.org/10.3390/ijms18081674
dc.description Publication history: Accepted - 28 July 2017; Published online - 1 August 2017 en_US
dc.description.abstract Due to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE) twenty-four animals with extreme phenotypes regarding residual feed intake (RFI) were analyzed. Transcriptome and fatty acid profiles of liver tissue were complemented with measurements on blood parameters and thyroid hormone levels. Based on 803 differentially-abundant probe sets between low- and high-FE animals, canonical pathways like integrin signaling and lipid and carbohydrate metabolism, were shown to be affected. Molecular alterations of lipid metabolism show a pattern of a reduced hepatic usage of fatty acids in high-FE animals. Complementary analyses at the systemic level exclusively pointed to increased circulating triglycerides which were, however, accompanied by considerably lower concentrations of saturated and polyunsaturated fatty acids in the liver of high-FE pigs. These results are in accordance with altered muscle-to-fat ratios usually ascribed to FE animals. It is concluded that strategies to improve FE might favor a metabolic shift from energy storage towards energy utilization and mobilization. en_US
dc.description.sponsorship This work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) as part of the ECO-FCE project under grant agreement No. 311794. The Leibniz Institute for Farm Animal Biology provided its own matched funding en_US
dc.language.iso en en_US
dc.publisher MDPI en_US
dc.rights © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). en_US
dc.subject feed efficiency en_US
dc.subject gene expression en_US
dc.subject lipid metabolism en_US
dc.subject liver en_US
dc.subject nutrient utilization en_US
dc.subject resource efficiency en_US
dc.title Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism en_US
dc.type Article en_US
dcterms.dateAccepted 2017-07-28
dcterms.dateSubmitted 2017-06-14

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