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A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir

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dc.contributor.author O'Hare, Anthony
dc.contributor.author Balaz, Daniel
dc.contributor.author Wright, David M.
dc.contributor.author McCormick, Carl
dc.contributor.author McDowell, Stanley W.J.
dc.contributor.author Trewby, Hannah
dc.contributor.author Skuce, Robin A.
dc.contributor.author Kao, Rowland r.
dc.date.accessioned 2021-08-13T11:27:35Z
dc.date.available 2021-08-13T11:27:35Z
dc.date.issued 2021-06-25
dc.identifier http://hdl.handle.net/20.500.12518/344
dc.identifier.citation O’Hare, A., Balaz, D., Wright, D. M., McCormick, C., McDowell, S., Trewby, H., Skuce, R. A. and Kao, R. R. (2021) ‘A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir’, PLOS Computational Biology. Edited by M. P. Davenport, 17(6), p. e1009005. doi: 10.1371/journal.pcbi.1009005. en_US
dc.identifier.issn 1553-734X
dc.identifier.issn 1553-7358
dc.identifier.uri https://doi.org/10.1371/journal.pcbi.1009005
dc.description Publication history: Accepted - 25 Aprl 2021; Published online - 25 June 2021. en_US
dc.description.abstract For single host pathogens, pathogen genetic data have been transformative for understanding the transmission and control of many diseases, particuarly rapidly evolving RNA viruses. However garnering similar insights where pathogens are multi-host is more challenging, particularly when the evolution of the pathogen is slower and pathogen sampling often heavily biased. This is the case for Mycobacterium bovis, the causative agent of bovine Tuberculosis (bTB) and for which the Eurasian badger plays an as yet poorly understood role in transmission and spread. Here we have developed a computational model that incorporates M. bovis genetic data from cattle only with a highly abstracted model of an unobserved reservoir. Our research shows that a model in which the reservoir does not contribute to pathogen diversity, but is a source of infection in spatially localised areas around each farm, better describes the patterns of outbreaks observed in a population-level sample of a single M. bovis genotype in Northern Ireland over a period of 15 years, compared to models in which either the reservoir has no role, disease spread is spatially extensive, or where they generate considerable diversity on their own. While this reservoir model is not explicitly a model of badgers, its characteristics are consistent with other data that would suggest a reservoir consisting of infected badgers that contribute substantially to cattle infection, but could not maintain disease on their own. en_US
dc.description.sponsorship This study was funded by the following research grants: i) Biotechnology and Biological Sciences Research Council (BB/L010569/1) was awarded to RRK and funded the work of DB, DMW, TM, CM, SM, RAS (www.bbsrc.ac.uk) ii) Biotechnology and Biological Sciences Research Council (BB/L010569/2) was awarded to RRK and funded the work of DB iii) A Wellcome Trust Senior Fellowship (081696/Z/06/Z) was awarded to RRK and funded the work of AOH (www.wellcome.ac.uk) iv) Biotechnology and Biological Sciences Research Council (BB/P010598/1) was awarded to RRK and funded his involvement v) Dept of Agriculture environment and Rural Affairs grant DARD0407 was awared to RAS and funded the work of TM, CM, SM (https://www.daera-ni.gov.uk). en_US
dc.language.iso en en_US
dc.publisher Public Library of Science en_US
dc.rights © 2021 O’Hare et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. en_US
dc.title A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir en_US
dc.type Article en_US
dcterms.dateAccepted 2021-04-25
dcterms.dateSubmitted 2020-07-27


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