Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells
Date
2012-09-03
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Frontiers Media
Abstract
Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host
responses through small non-coding RNA (sncRNA) expression. We show that RSV
or MeV infection of neuronal cells induces sncRNAs including various microRNAs and
transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs
(GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine).
Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous
codon usage indices suggesting selective cleavage of the tRNAs occurs in infected
neuronal cells. The data implies that differentially expressed sncRNAs may regulate host
gene expression via multiple mechanisms in neuronal cells.
Description
Publication history: Accepted - 3 August 2021; Published - 3 September 2021.
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Keywords
respiratory syncytial virus, measles virus, neuronal cells, microRNAs, piwi-associated RNAs, transfer RNAs
Citation
Bakre, A. A., Duffy, C., Abdullah, H., Cosby, S. L. and Tripp, R. A. (2021) āSmall Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cellsā, Frontiers in Microbiology, 12. doi: 10.3389/fmicb.2021.671852.