DSpace Repository

Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells

Show simple item record

dc.contributor.author Bakre, Abhijeet A.
dc.contributor.author Duffy, Catherine
dc.contributor.author Abdullah, Hani’ah
dc.contributor.author Cosby, S. Louise
dc.contributor.author Tripp, Ralph A.
dc.date.accessioned 2021-09-17T15:28:56Z
dc.date.available 2021-09-17T15:28:56Z
dc.date.issued 2012-09-03
dc.identifier http://hdl.handle.net/20.500.12518/353
dc.identifier.citation Bakre, A. A., Duffy, C., Abdullah, H., Cosby, S. L. and Tripp, R. A. (2021) ‘Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells’, Frontiers in Microbiology, 12. doi: 10.3389/fmicb.2021.671852. en_US
dc.identifier.issn 1664-302X (electronic)
dc.identifier.uri https://doi.org/10.3389/fmicb.2021.671852
dc.description Publication history: Accepted - 3 August 2021; Published - 3 September 2021. en_US
dc.description.abstract Respiratory syncytial virus (RSV) or measles virus (MeV) infection modifies host responses through small non-coding RNA (sncRNA) expression. We show that RSV or MeV infection of neuronal cells induces sncRNAs including various microRNAs and transfer RNA fragments (tRFs). We show that these tRFs originate from select tRNAs (GCC and CAC for glycine, CTT and AAC for Valine, and CCC and TTT for Lysine). Some of the tRNAs are rarely used by RSV or MeV as indicated by relative synonymous codon usage indices suggesting selective cleavage of the tRNAs occurs in infected neuronal cells. The data implies that differentially expressed sncRNAs may regulate host gene expression via multiple mechanisms in neuronal cells. en_US
dc.description.sponsorship The studies were supported by a grant awarded to SC and RT (IE140652) to study “Paramyxovirus miRNA biogenesis and implications for host and viral gene expression” and the Georgia Research Alliance Foundation for RT. en_US
dc.language.iso en en_US
dc.publisher Frontiers Media en_US
dc.rights Copyright © 2021 Bakre, Duffy, Abdullah, Cosby and Tripp. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. en_US
dc.subject respiratory syncytial virus en_US
dc.subject measles virus en_US
dc.subject neuronal cells en_US
dc.subject microRNAs en_US
dc.subject piwi-associated RNAs en_US
dc.subject transfer RNAs en_US
dc.title Small Non-coding RNA Expression Following Respiratory Syncytial Virus or Measles Virus Infection of Neuronal Cells en_US
dc.type Article en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

Search


Browse

My Account