Common themes in antimicrobial and anticancer drug resistance
Date
2022-08-08
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Publisher
Frontiers Media
Abstract
Antimicrobial and anticancer drug resistance represent two of the main global
challenges for the public health, requiring immediate practical solutions. In
line with this, we need a better understanding of the origins of drug resistance
in prokaryotic and eukaryotic cells and the evolutionary processes leading
to the occurrence of adaptive phenotypes in response to the selective
pressure of therapeutic agents. The purpose of this paper is to present some
of the analogies between the antimicrobial and anticancer drug resistance.
Antimicrobial and anticancer drugs share common targets and mechanisms of
action as well as similar mechanisms of resistance (e.g., increased drug efflux,
drug inactivation, target alteration, persister cells’ selection, protection of
bacterial communities/malignant tissue by an extracellular matrix, etc.). Both
individual and collective stress responses triggered by the chemotherapeutic
agent involving complex intercellular communication processes, as well as
with the surrounding microenvironment, will be considered. The common
themes in antimicrobial and anticancer drug resistance recommend the utility
of bacterial experimental models for unraveling the mechanisms that facilitate
the evolution and adaptation of malignant cells to antineoplastic drugs.
Description
Publication history: Accepted - 22 July 2022; Published - 8 August 2022.
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Keywords
microbial biofilms, persister cells, efflux pumps, stress response, gut microbiota, mutator phenotype
Citation
Chifiriuc, M.C., Filip, R., Constantin, M., Pircalabioru, G.G., Bleotu, C., Burlibasa, L., Ionica, E., Corcionivoschi, N. and Mihaescu, G. (2022) ‘Common themes in antimicrobial and anticancer drug resistance’, Frontiers in Microbiology. Frontiers Media SA. Available at: https://doi.org/10.3389/fmicb.2022.960693.