The Prebiotic Effect of an Organic Acid Mixture on Faecalibacterium prausnitzii Metabolism and Its Anti-Pathogenic Role against Vibrio parahaemolyticus in Shrimp

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dc.contributor.authorButucel, Eugenia
dc.contributor.authorBalta, Igori
dc.contributor.authorMcCleery, David
dc.contributor.authorMarcu, Adela
dc.contributor.authorStef, Ducu
dc.contributor.authorPet, Ioan
dc.contributor.authorCallaway, Todd
dc.contributor.authorStef, Lavinia
dc.contributor.authorCorcionivoschi, Nicolae
dc.date.accessioned2023-01-10T16:31:06Z
dc.date.available2023-01-10T16:31:06Z
dc.date.issued2022-12-29
dc.descriptionPublication history: Accepted - 27 December 2022; Published - 29 December 2022.en_US
dc.description.abstractIncreasing the abundance of probiotic bacteria in the gut requires either direct dietary supplementation or the inclusion of feed additives able to support the growth of beneficial commensal bacteria. In crustaceans, the increased presence of probiotic-like bacteria in the gut, including of Faecalibacterium prausnitzii (F. prausnitzii), will guarantee a positive health status and a gut environment that will ensure enhanced performance. The aim of this study was to investigate if a mixture of organic acids, AuraAqua (Aq) can stimulate the growth and the anti-pathogenic efficacy of F. prausnitzii through a combination of in vitro and ex vivo models. The results showed that 0.5% Aq was able to improve the growth rate of F. prausnitzii in vitro and in an ex vivo shrimp gut model. Moreover, we were able to demonstrate that Aq increases butyrate production and cellulose degradation in culture or in the shrimp gut model. The growth-stimulating effect of Aq also led to an improved and anti-pathogenic effect against Vibrio parahaemolyticus in a co-culture experiment with shrimp gut primary epithelial cells (SGP). In conclusion, our work demonstrates that Aq can stimulate the growth of F. prausnitzii, increase the production of short-chain fatty acid (SCFA) butyrate, improve substrate digestion, and prevent V. parahaemolyticus invasion of SGP cells.en_US
dc.description.sponsorshipWe acknowledge Environtech, Dublin, Ireland for funding the PhD of Eugenia Butucel. Grant number 49650.en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/509
dc.identifier.citationButucel, E., Balta, I., McCleery, D., Marcu, A., Stef, D., Pet, I., Callaway, T., Stef, L. and Corcionivoschi, N. (2022) ‘The Prebiotic Effect of an Organic Acid Mixture on Faecalibacterium prausnitzii Metabolism and Its Anti-Pathogenic Role against Vibrio parahaemolyticus in Shrimp’, Biology. MDPI AG. Available at: https://doi.org/10.3390/biology12010057.en_US
dc.identifier.issn2079-7737 (electronic)
dc.identifier.urihttps://doi.org/10.3390/biology12010057
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.subjectFaecalibacterium prausnitziien_US
dc.subjectVibrio parahaemolyticusen_US
dc.subjectprebioticsen_US
dc.subjectprobioticsen_US
dc.subjectbacterial growthen_US
dc.subjectbutyrateen_US
dc.subjectvirulenceen_US
dc.subjectprimary epithelial cellsen_US
dc.titleThe Prebiotic Effect of an Organic Acid Mixture on Faecalibacterium prausnitzii Metabolism and Its Anti-Pathogenic Role against Vibrio parahaemolyticus in Shrimpen_US
dc.typeArticleen_US
dcterms.dateAccepted2022-12-27
dcterms.dateSubmitted2022-11-24

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