Anti-Campylobacter Probiotics: Latest Mechanistic Insights

Simple item page
dc.contributor.authorBalta, Igori
dc.contributor.authorButucel, Eugenia
dc.contributor.authorStef, Lavinia
dc.contributor.authorPet, Ioan
dc.contributor.authorGradisteanu-Pircalabioru, Gratiela
dc.contributor.authorChifiriuc, Carmen
dc.contributor.authorGundogdu, Ozan
dc.contributor.authorMcCleery, David
dc.contributor.authorCorcionivoschi, Nicolae
dc.date.accessioned2022-09-07T13:17:13Z
dc.date.available2022-09-07T13:17:13Z
dc.date.issued2022-07-29
dc.descriptionPublication history: Published online ahead of print - 29 July 2022.en_US
dc.description.abstractThe Campylobacter genus is the leading cause of human gastroenteritis, with the consumption of contaminated poultry meat as the main route of infection. Probiotic bacteria, such as Lactobacillus, Bacillus, Escherichia coli Nissle, and Bifidobacterium species, have a great immunomodulatory capacity and exhibit antipathogenic effects through various molecular mechanisms. Reducing Campylobacter levels in livestock animals, such as poultry, will have a substantial benefit to humans as it will reduce disease transmissibility through the food chain. Moreover, probiotic-based strategies might attenuate intestinal inflammatory processes, which consequently reduce the severity of Campylobacter disease progression. At a molecular level, probiotics can also negatively impact on the functionality of various Campylobacter virulence and survival factors (e.g., adhesion, invasion), and on the associated colonization proteins involved in epithelial translocation. The current review describes recent in vitro, in vivo, and preclinical findings on probiotic therapies, aiming to reduce Campylobacter counts in poultry and reduce the pathogen’s virulence in the avian and human host. Moreover, we focused in particular on probiotics with known anti-Campylobacter activity seeking to understand the biological mechanisms involved in their mode of action.en_US
dc.description.sponsorshipNoneen_US
dc.identifierhttp://hdl.handle.net/20.500.12518/479
dc.identifier.citationBalta,I., Butucel, E., Stef, L., Pet, I., Gradisteanu-Pircalabioru, G., Chifiriuc, C., Gundogdu, O., McCleery, D. and Corcionivoschi, N. (2022) 'Anti-Campylobacter Probiotics: Latest Mechanistic Insights', Foodborne Pathogens and Disease. Mary Ann Liebert. doI:10.1089/fpd.2022.0039en_US
dc.identifier.issn1535-3141
dc.identifier.issn1556-7125 (electronic)
dc.identifier.urihttps://doi.org/10.1089/fpd.2022.0039
dc.language.isoenen_US
dc.publisherMary Ann Lieberten_US
dc.rightsCopyright Igori Balta et al. 2022; This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.subjectprobioticsen_US
dc.subjectCampylobacter spp.en_US
dc.subjectmechanismsen_US
dc.subjectpoultryen_US
dc.subjecthumansen_US
dc.titleAnti-Campylobacter Probiotics: Latest Mechanistic Insightsen_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Anti-Campylobacter Probiotics-Latest Mechanistic Insights.pdf
Size:
630.4 KB
Format:
Adobe Portable Document Format
Description:
Final published version
Download

Collections

Journal Articles