Urinary glucocorticoids in harbour seal (Phoca vitulina) pups during rehabilitation

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dc.contributor.authorWilson, Susan C.
dc.contributor.authorVillanueva, Stella
dc.contributor.authorJones, Kayleigh A.
dc.contributor.authorDmitrieva, Lilia
dc.contributor.authorSmyth, Wesley
dc.date.accessioned2023-04-04T13:30:21Z
dc.date.available2023-04-04T13:30:21Z
dc.date.issued2023-02-10
dc.descriptionPublication history: Accepted - 8 February 2023; Published online - 10 February 2023
dc.description.abstractThe glucocorticoid (GC) hormone cortisol is often measured in seals to indicate their stress levels, although other endogenous GCs are usually overlooked. We investigated concentrations of four endogenous GCs in the urine of “orphan” harbour seal pups in rehabilitation. We hypothesised that the GC levels would be elevated if pups were socially isolated, without water access, and with low body mass. Ninety-six samples were collected from 32 pups at four different rehabilitation centres and were analysed by Ultra Performance Liquid Chromatography and Tandem Mass Spectrometry. Median urinary creatinine (Cr) concentrations of endogenous prednisolone (31.6 ng/mg/Cr) and prednisone (31.1 ng/mg/Cr) occurred in similar magnitude to cortisol (37.0 ng/mg/Cr), while median cortisone concentrations were higher (390 ng/mg/Cr). Prednisolone and prednisone concentrations were more strongly inversely related to pup growth rate and pup mass than cortisol and cortisone. Concentrations of all four GCs decreased with mass gain for pups with water access but did not decrease for pups without water; linear mixed models indicated the interaction between these trends was significant for cortisol and cortisone, but not for prednisolone or prednisone. These results indicate the potential value of measuring all four of these endogenous GC hormones in phocid seal pups.
dc.description.sponsorshipThis study has not received any grant from any funding agency.
dc.identifierhttps://hdl.handle.net/20.500.12518/535
dc.identifier.citationWilson, S.C., Villanueva, S., Jones, K.A., Dmitrieva, L. and Smyth, W. (2023) ‘Urinary glucocorticoids in harbour seal (Phoca vitulina) pups during rehabilitation’, General and Comparative Endocrinology. Elsevier BV. Available at: https://doi.org/10.1016/j.ygcen.2023.114227.
dc.identifier.issn0016-6480
dc.identifier.urihttps://doi.org/10.1016/j.ygcen.2023.114227
dc.language.isoen
dc.publisherElsevier
dc.rights© 2023 Elsevier Inc. CC-BY-NC-ND. This manuscript is distributed under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
dc.subjectHarbor seal
dc.subjectCortisol
dc.subjectGlucocorticoid
dc.subjectRehabilitation
dc.subjectStress
dc.subjectEnvironment
dc.titleUrinary glucocorticoids in harbour seal (Phoca vitulina) pups during rehabilitation
dc.typeArticle
dcterms.dateAccepted2023-02-08
dcterms.dateSubmitted2021-11-29

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