The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3

Simple item page
dc.contributor.authorLagan Tregaskis, Paula
dc.contributor.authorDevaney, Ryan
dc.contributor.authorSmyth, Victoria
dc.date.accessioned2021-02-16T14:37:04Z
dc.date.available2021-02-16T14:37:04Z
dc.date.issued2021-02-03
dc.descriptionPublication history: Accepted - 27 January 2021; Published - 3 February 2021.en_US
dc.description.abstractAvian nephritis virus (ANV) is classified in the Avastroviridae family with disease associations with nephritis, uneven flock growth and runting stunting syndrome (RSS) in chicken and turkey flocks, and other avian species. The whole genome of ANV genotype 3 (ANV-3) of 6959 nucleotides including the untranslated 5’ and 3’ regions and polyadenylated tail was detected in a metagenomic virome investigation of RSS-affected chicken broiler flocks. This report characterises the ANV-3 genome, identifying partially overlapping open reading frames (ORFs), ORF1a and ORF1b, and an opposing secondary pseudoknot prior to a ribosomal frameshift stemloop structure, with a separate ORF2, whilst observing conserved astrovirus motifs. Phylogenetic analysis of the Avastroviridae whole genome and ORF2 capsid polyprotein classified the first complete whole genome of ANV-3 within Avastroviridae genogroup 2.en_US
dc.description.sponsorshipThis research was partially funded by the Department of Agriculture, Environment & Rural Affairs—Code PG 13/02, and the Agri-Food and Biosciences Institute (AFBI)—Code 44955.en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/213
dc.identifier.citationLagan Tregaskis, P., Devaney, R. and Smyth, V. J. (2021) ‘The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3’, Viruses. MDPI AG, 13(2), p. 235. doi: 10.3390/v13020235.en_US
dc.identifier.issn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v13020235
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).en_US
dc.subjectavian nephritis virusen_US
dc.subjectastrovirusen_US
dc.subjectphylogeneticsen_US
dc.subjectmolecular characterisationen_US
dc.subjectgenotyping and recombinationen_US
dc.titleThe First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3en_US
dc.typeArticleen_US

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
The First Whole Genome Sequence and Characterisation of Avian Nephritis Virus Genotype 3.pdf
Size:
6.06 MB
Format:
Adobe Portable Document Format
Description:
Final Published Version
Download

Collections

Journal Articles