Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism

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dc.contributor.authorReyer, Henry
dc.contributor.authorOster, Michael
dc.contributor.authorMagowan, Elizabeth
dc.contributor.authorDannenberger, Dirk
dc.contributor.authorPonsuksili, Siriluck
dc.contributor.authorWimmers, Klaus
dc.date.accessioned2021-07-16T13:39:57Z
dc.date.available2021-07-16T13:39:57Z
dc.date.issued2017-08-01
dc.descriptionPublication history: Accepted - 28 July 2017; Published online - 1 August 2017en_US
dc.description.abstractDue to the central role of liver tissue in partitioning and metabolizing of nutrients, molecular liver-specific alterations are of considerable interest to characterize an efficient conversion and usage of feed in livestock. To deduce tissue-specific and systemic effects on nutrient metabolism and feed efficiency (FE) twenty-four animals with extreme phenotypes regarding residual feed intake (RFI) were analyzed. Transcriptome and fatty acid profiles of liver tissue were complemented with measurements on blood parameters and thyroid hormone levels. Based on 803 differentially-abundant probe sets between low- and high-FE animals, canonical pathways like integrin signaling and lipid and carbohydrate metabolism, were shown to be affected. Molecular alterations of lipid metabolism show a pattern of a reduced hepatic usage of fatty acids in high-FE animals. Complementary analyses at the systemic level exclusively pointed to increased circulating triglycerides which were, however, accompanied by considerably lower concentrations of saturated and polyunsaturated fatty acids in the liver of high-FE pigs. These results are in accordance with altered muscle-to-fat ratios usually ascribed to FE animals. It is concluded that strategies to improve FE might favor a metabolic shift from energy storage towards energy utilization and mobilization.en_US
dc.description.sponsorshipThis work was funded by the European Union Seventh Framework Programme (FP7/2007–2013) as part of the ECO-FCE project under grant agreement No. 311794. The Leibniz Institute for Farm Animal Biology provided its own matched fundingen_US
dc.identifierhttp://hdl.handle.net/20.500.12518/320
dc.identifier.citationReyer, H., Oster, M., Magowan, E., Dannenberger, D., Ponsuksili, S. and Wimmers, K. (2017) ‘Strategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolism’, International Journal of Molecular Sciences, 18(8), p. 1674. doi: 10.3390/ijms18081674.en_US
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.urihttps://doi.org/10.3390/ijms18081674
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.rights© 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).en_US
dc.subjectfeed efficiencyen_US
dc.subjectgene expressionen_US
dc.subjectlipid metabolismen_US
dc.subjectliveren_US
dc.subjectnutrient utilizationen_US
dc.subjectresource efficiencyen_US
dc.titleStrategies towards Improved Feed Efficiency in Pigs Comprise Molecular Shifts in Hepatic Lipid and Carbohydrate Metabolismen_US
dc.typeArticleen_US
dcterms.dateAccepted2017-07-28
dcterms.dateSubmitted2017-06-14

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