Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo

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dc.contributor.authorBalta, Igori
dc.contributor.authorStef, Lavinia
dc.contributor.authorPet, Ioan
dc.contributor.authorWard, Patrick
dc.contributor.authorCallaway, Todd
dc.contributor.authorRicke, Steven C.
dc.contributor.authorGundogdu, Ozan
dc.contributor.authorCorcionivoschi, Nicolae
dc.contributor.departmentAnimal Health and Welfare
dc.date.accessioned2024-02-28T14:58:10Z
dc.date.available2024-02-28T14:58:10Z
dc.date.issued2020-10-06
dc.descriptionPublication history: Accepted - 21 September 2020; Published - 6 October 2020.
dc.description.abstractThe aim of this study was to test in vitro the ability of a mixture of citrus extract, maltodextrin, sodium chloride, lactic acid and citric acid (AuraShield L) to inhibit the virulence of infectious bronchitis, Newcastle disease, avian influenza, porcine reproductive and respiratory syndrome (PRRS) and bovine coronavirus viruses. Secondly, in vivo, we have investigated its efficacy against infectious bronchitis using a broiler infection model. In vitro, these antimicrobials had expressed antiviral activity against all five viruses through all phases of the infection process of the host cells. In vivo, the antimicrobial mixture reduced the virus load in the tracheal and lung tissue and significantly reduced the clinical signs of infection and the mortality rate in the experimental group E2 receiving AuraShield L. All these effects were accompanied by a significant reduction in the levels of pro-inflammatory cytokines and an increase in IgA levels and short chain fatty acids (SCFAs) in both trachea and lungs. Our study demonstrated that mixtures of natural antimicrobials, such AuraShield L, can prevent in vitro viral infection of cell cultures. Secondly, in vivo, the efficiency of vaccination was improved by preventing secondary viral infections through a mechanism involving significant increases in SCFA production and increased IgA levels. As a consequence the clinical signs of secondary infections were significantly reduced resulting in recovered production performance and lower mortality rates in the experimental group E2.
dc.description.sponsorshipThis study was supported by a grant awarded to Environtech, Dublin, Ireland.
dc.identifierhttps://hdl.handle.net/20.500.12518/646
dc.identifier.citationBalta, I., Stef, L., Pet, I., Ward, P., Callaway, T., Ricke, S.C., Gundogdu, O. and Corcionivoschi, N. (2020) ‘Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo’, Scientific Reports. Springer Science and Business Media LLC. Available at: https://doi.org/10.1038/s41598-020-73916-1.
dc.identifier.issn2045-2322 (electronic)
dc.identifier.urihttps://doi.org/10.1038/s41598-020-73916-1
dc.language.isoen
dc.publisherSpringer Nature
dc.rights© The Author(s) 2020. Open Access - This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.subjectChemokines
dc.subjectViral host response
dc.titleAntiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo
dc.typeArticle
dcterms.dateAccepted2020-09-21
dcterms.dateSubmitted2020-05-26

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