Nematode neuropeptides as transgenic nematicides

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dc.contributor.authorWarnock, Neil D.
dc.contributor.authorWilson, Leonie
dc.contributor.authorPatten, Cheryl
dc.contributor.authorFleming, Colin C.
dc.contributor.authorMaule, Aaron G.
dc.contributor.authorDalzell, Johnathan
dc.date.accessioned2021-07-16T13:31:44Z
dc.date.available2021-07-16T13:31:44Z
dc.date.issued2017-02-27
dc.descriptionNDW was supported by a Bill and Melinda Gates Foundation grand challenge exploration grant. LW was supported by a PhD studentship from the EUPHRESCO Plant Health Fellowship Scheme, and an Eaton Visitorship Award. JJD was supported by a Leverhulme Trust early career fellowship and a Bill and Melinda Gates Foundation grand challenge exploration grant.en_US
dc.description.abstractPlant parasitic nematodes (PPNs) seriously threaten global food security. Conventionally an integrated approach to PPN management has relied heavily on carbamate, organophosphate and fumigant nematicides which are now being withdrawn over environmental health and safety concerns. This progressive withdrawal has left a significant shortcoming in our ability to manage these economically important parasites, and highlights the need for novel and robust control methods. Nematodes can assimilate exogenous peptides through retrograde transport along the chemosensory amphid neurons. Peptides can accumulate within cells of the central nerve ring and can elicit physiological effects when released to interact with receptors on adjoining cells. We have profiled bioactive neuropeptides from the neuropeptide-like protein (NLP) family of PPNs as novel nematicides, and have identified numerous discrete NLPs that negatively impact chemosensation, host invasion and stylet thrusting of the root knot nematode Meloidogyne incognita and the potato cyst nematode Globodera pallida. Transgenic secretion of these peptides from the rhizobacterium, Bacillus subtilis, and the terrestrial microalgae Chlamydomonas reinhardtii reduce tomato infection levels by up to 90% when compared with controls. These data pave the way for the exploitation of nematode neuropeptides as a novel class of plant protective nematicide, using novel non-food transgenic delivery systems which could be deployed on farmer-preferred cultivars.en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/319
dc.identifier.citationWarnock, N. D., Wilson, L., Patten, C., Fleming, C. C., Maule, A. G. and Dalzell, J. J. (2017) ‘Nematode neuropeptides as transgenic nematicides’, PLOS Pathogens. Edited by D. Mackey, 13(2), p. e1006237. doi: 10.1371/journal.ppat.1006237.en_US
dc.identifier.issn1553-7366
dc.identifier.issn1553-7374
dc.identifier.urihttps://doi.org/10.1371/journal.ppat.1006237
dc.language.isoenen_US
dc.publisherPublic Library of Scienceen_US
dc.rights© 2017 Warnock et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.titleNematode neuropeptides as transgenic nematicidesen_US
dc.typeArticleen_US
dcterms.dateAccepted2017-02-14
dcterms.dateSubmitted2016-10-16

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