Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry

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dc.contributor.authorUgarte-Ruiz, Maria
dc.contributor.authorDomínguez, Lucas
dc.contributor.authorCorcionivoschi, Nicolae
dc.contributor.authorWren, Brendan W.
dc.contributor.authorDorrell, Nick
dc.contributor.authorGundogdu, Ozan
dc.date.accessioned2021-06-24T08:40:37Z
dc.date.available2021-06-24T08:40:37Z
dc.date.issued2018-06-19
dc.descriptionPublication history: Accepted - 13 June 2018; Published online - 19 June 2018.en_US
dc.description.abstractCampylobacter jejuni is the leading cause of food-borne bacterial enteritis in humans, with contaminated poultry products considered the main source of infection. To survive the food chain, C. jejuni utilizes multiple defense mechanisms that counter oxidative and aerobic stresses. In this study, we phenotypically characterised 63 C. jejuni strains with oxidative stress survival and antimicrobial susceptibility testing to investigate correlations between these two phenotypes against the source of the strains and the presence of the MarR regulators RrpA and RrpB which have a role in regulating the response to oxidative and aerobic stress. C. jejuni strains isolated from meat and neck skin displayed the highest resistance to oxidative stress. In addition, C. jejuni strains that have an rrpA+rrpB− profile exhibit increased resistance to oxidative stress and to antimicrobials. Here we establish a preliminary link between the distribution of RrpA and RrpB and the increased resistance to antimicrobials. This study provides insight into how the genotypic make up of C. jejuni can influence the ability of the bacterium to survive within areas of high oxygen stress, such as the food chain, and subsequently can have a potential negative impact on human health.en_US
dc.description.sponsorshipThis work was partially supported by the Ministry of Science and Innovation (AGL2009-07550; AGL2012-39028) and by the Autonomous Community of Madrid, Spain (S2009/AGR-1489; S2013/ ABI-2747). M. Ugarte-Ruiz was supported by the FPU programme (AP2009- 1747) from the Spanish Ministry of Education, Culture and Sports during her stage at London School of Hygiene & Tropical Medicine (2013).en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/301
dc.identifier.citationUgarte-Ruiz, M., Domínguez, L., Corcionivoschi, N., Wren, B.W., Dorrell, N. and Gundogdu, O. (2018) ‘Exploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultry’, Research in Veterinary Science. Elsevier BV. doi:10.1016/j.rvsc.2018.06.016en_US
dc.identifier.issn0034-5288
dc.identifier.urihttps://doi.org/10.1016/j.rvsc.2018.06.016
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rights© 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).en_US
dc.subjectCampylobacter jejunien_US
dc.subjectOxidative stressen_US
dc.subjectAntimicrobial resistanceen_US
dc.subjectMarR domainen_US
dc.titleExploring the oxidative, antimicrobial and genomic properties of Campylobacter jejuni strains isolated from poultryen_US
dc.typeArticleen_US

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