Can We Breed Cattle for Lower Bovine TB Infectivity?

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dc.contributor.authorTsairidou, Smaragda
dc.contributor.authorAllen, Adrian
dc.contributor.authorBanos, Georgios
dc.contributor.authorCoffey, Mike
dc.contributor.authorAnacleto, Osvaldo
dc.contributor.authorByrne, Andrew W.
dc.contributor.authorSkuce, Robin
dc.contributor.authorGlass, Elizabeth J.
dc.contributor.authorWoolliams, John A.
dc.contributor.authorDoeschl-Wilson, Andrea B.
dc.date.accessioned2021-06-24T08:53:01Z
dc.date.available2021-06-24T08:53:01Z
dc.date.issued2018-12-07
dc.descriptionPublication history: Accepted - 22 November 2018; Published - 7 December 2018.en_US
dc.description.abstractHost resistance and infectivity are genetic traits affecting infectious disease transmission. This Perspective discusses the potential exploitation of genetic variation in cattle infectivity, in addition to resistance, to reduce the risk, and prevalence of bovine tuberculosis (bTB). In bTB, variability in M. bovis shedding has been previously reported in cattle and wildlife hosts (badgers and wild boars), but the observed differences were attributed to dose and route of infection, rather than host genetics. This article addresses the extent to which cattle infectivity may play a role in bTB transmission, and discusses the feasibility, and potential benefits from incorporating infectivity into breeding programmes. The underlying hypothesis is that bTB infectivity, like resistance, is partly controlled by genetics. Identifying and reducing the number of cattle with high genetic infectivity, could reduce further a major risk factor for herds exposed to bTB. We outline evidence in support of this hypothesis and describe methodologies for detecting and estimating genetic parameters for infectivity. Using genetic-epidemiological predictionmodels we discuss the potential benefits of selection for reduced infectivity and increased resistance in terms of practical field measures of epidemic risk and severity. Simulations predict that adding infectivity to the breeding programme could enhance and accelerate the reduction in breakdown risk compared to selection on resistance alone. Therefore, given the recent launch of genetic evaluations for bTB resistance and the UK government’s goal to eradicate bTB, it is timely to consider the potential of integrating infectivity into breeding schemes.en_US
dc.description.sponsorshipThis work was carried out with funding from the Biotechnology and Biological Sciences Research Council Institute Strategic Programme grants BB/J004235/1 (ISP1) and BB/P013740/1 (ISP2) (OA, AD-W, GB and JW), and the European Union FP7 project FISHBOOST (KBBE - 7-613611) (ST). GB was also supported by the Rural and Environment Science and Analytical Services Division of the Scottish Government.en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/302
dc.identifier.citationTsairidou, S., Allen, A., Banos, G., Coffey, M., Anacleto, O., Byrne, A. W., Skuce, R. A., Glass, E. J., Woolliams, J. A. and Doeschl-Wilson, A. B. (2018) ‘Can We Breed Cattle for Lower Bovine TB Infectivity?’, Frontiers in Veterinary Science, 5. doi: 10.3389/fvets.2018.00310.en_US
dc.identifier.issn2297-1769 (electronic)
dc.identifier.urihttps://doi.org/10.3389/fvets.2018.00310
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.rightsCopyright © 2018 Tsairidou, Allen, Banos, Coffey, Anacleto, Byrne, Skuce, Glass, Woolliams and Doeschl-Wilson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.subjectdisease resistanceen_US
dc.subjectdisease controlen_US
dc.subjectanimal breedingen_US
dc.subjectinfectivityen_US
dc.subjectbovine Tuberculosisen_US
dc.titleCan We Breed Cattle for Lower Bovine TB Infectivity?en_US
dc.typeArticleen_US

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