Meta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK andIreland

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dc.contributor.authorNuñez-Garcia, Javier
dc.contributor.authorDowns, Sara H.
dc.contributor.authorParrya, Jessica E.
dc.contributor.authorAbernethy, Darrell A.
dc.contributor.authorBroughan, Jennifer M.
dc.contributor.authorCameron, Angus R.
dc.contributor.authorCook, Alasdair J.
dc.contributor.authorde la Rua-Domenech, Ricardo
dc.contributor.authorGoodchild, Anthony V.
dc.contributor.authorGunn, Jane
dc.contributor.authorMore, Simon J.
dc.contributor.authorRhodes, Shelley
dc.contributor.authorRolfe, Simon
dc.contributor.authorSharp, Michael
dc.contributor.authorUpton, Paul A.
dc.contributor.authorVordermeier, H. Martin
dc.contributor.authorWatson, Eamon
dc.contributor.authorWelsh, Michael
dc.contributor.authorWhelan, Adam O.
dc.contributor.authorWoolliams, John A.
dc.contributor.authorClifton-Hadley, Richard S.
dc.contributor.authorGreiner, Matthias
dc.date.accessioned2021-06-07T13:42:21Z
dc.date.available2021-06-07T13:42:21Z
dc.date.issued2017-03-06
dc.descriptionPublication history: Accepted - 26 February 2017; Published online - 6th March 2017.en_US
dc.description.abstractBovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accu-rate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was,through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 differ-ent ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic reviewof the scientific literature (published 1934–2009) diagnostic Se and Sp were estimated using Bayesianlogistic regression models adjusting for confounding factors. Random effect terms were used to accountfor unexplained heterogeneity. Parameters in the models were implemented using Markov Chain MonteCarlo (MCMC), and posterior distributions for the diagnostic parameters with adjustment for covariates(confounding factors) were obtained using the inverse logit function. Estimates for Se and/or Sp of thetuberculin skin tests and the IFN- blood test were compared with estimates published 2010–2015.Median Se for the single intradermal comparative cervical tuberculin skin (SICCT) test (standard inter-pretation) was 0.50 and Bayesian credible intervals (CrI) were wide (95% CrI 0.26, 0.78). Median Sp forthe SICCT test was 1.00 (95% CrI 0.99, 1.00). Estimates for the IFN- blood test Bovine Purified ProteinDerivative (PPD)-Avian PPD and Early Secreted Antigen target 6 and Culture Filtrate Protein 10 (ESAT-6/CFP10) ESAT6/CFP10 were 0.67 (95% CrI 0.49, 0.82) and 0.78 (95% CrI 0.60, 0.90) respectively for Se,and 0.98 (95% CrI 0.96, 0.99) and 0.99 (95% CrI 0.99, 1.00) for Sp. The study provides an overview of theaccuracy of a range of contemporary diagnostic tests for bTB in cattle. Better understanding of diagnostictest performance is essential for the design of effective control strategies and their evaluation.en_US
dc.description.sponsorshipThe SE3238 project “Meta-analysis of diagnostic tests and modelling to identify appropriate testing strategies to reduce M. bovis infection in GB herds” was funded by the UK Department for Envi-ronment, Food and Rural Affairs (Defra).en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/261
dc.identifier.citationNuñez-Garcia, J., Downs, S. H., Parry, J. E., Abernethy, D. A., Broughan, J. M., Cameron, A. R., Cook, A. J., de la Rua-Domenech, R., Goodchild, A. V., Gunn, J., More, S. J., Rhodes, S., Rolfe, S., Sharp, M., Upton, P. A., Vordermeier, H. M., Watson, E., Welsh, M., Whelan, A. O., Woolliams, J. A., Clifton-Hadley, R. S. and Greiner, M. (2018) ‘Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland’, Preventive Veterinary Medicine, 153, pp. 94–107. doi: 10.1016/j.prevetmed.2017.02.017.en_US
dc.identifier.issn0167-5877
dc.identifier.urihttps://doi.org/10.1016/j.prevetmed.2017.02.017
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsCrown Copyright © 2017 Published by Elsevier B.V. This is an open access article under the OpenGovernment License (OGL) (http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/).en_US
dc.subjectBovine tuberculosisen_US
dc.subjectDiagnostic testsen_US
dc.subjectMeta-analysisen_US
dc.subjectPerformanceen_US
dc.subjectSensitivityen_US
dc.subjectSpecificityen_US
dc.titleMeta-analyses of the sensitivity and specificity of ante-mortem andpost-mortem diagnostic tests for bovine tuberculosis in the UK andIrelanden_US
dc.typeArticleen_US

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