Evaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADAS

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dc.contributor.authorDowns, Sara H.
dc.contributor.authorMore, Simon J.
dc.contributor.authorGoodchild, Anthony V.
dc.contributor.authorWhelan, Adam O.
dc.contributor.authorAbernethy, Darrell A.
dc.contributor.authorBroughan, Jennifer M.
dc.contributor.authorCameron, Angus
dc.contributor.authorCook Alasdair J.
dc.contributor.authorde la Rua-Domenech, R. Ricardo
dc.contributor.authorGreiner, Matthias
dc.contributor.authorGunn, Jane
dc.contributor.authorNunez-Garcia Javier
dc.contributor.authorRhodes, Shelley
dc.contributor.authorRolfe, Simon
dc.contributor.authorSharp, Michael
dc.contributor.authorUpton, Paul
dc.contributor.authorWatson, Eamon
dc.contributor.authorWelsh, Michael
dc.contributor.authorWoolliams, John A.
dc.contributor.authorClifton-Hadley, Richard S.
dc.contributor.authorParry, Jessica E.
dc.date.accessioned2021-06-23T11:21:36Z
dc.date.available2021-06-23T11:21:36Z
dc.date.issued2017-03-22
dc.descriptionPublication history: Accepted - 18 March 2017; Published online - 22 March 2017en_US
dc.description.abstractThere has been little assessment of the methodological quality of studies measuring the performance (sensitivity and/or specificity) of diagnostic tests for animal diseases. In a systematic review, 190 studies of tests for bovine tuberculosis (bTB) in cattle (published 1934–2009) were assessed by at least one of 18 reviewers using the QUADAS (Quality Assessment of Diagnostic Accuracy Studies) checklist adapted for animal disease tests. VETQUADAS (VQ) included items measuring clarity in reporting (n = 3), internal validity (n = 9) and external validity (n = 2). A similar pattern for compliance was observed in studies of different diagnostic test types. Compliance significantly improved with year of publication for all items measuring clarity in reporting and external validity but only improved in four of the nine items measuring internal validity (p < 0.05). 107 references, of which 83 had performance data eligible for inclusion in a meta-analysis were reviewed by two reviewers. In these references, agreement between reviewers’ responses was 71% for compliance, 32% for unsure and 29% for non-compliance. Mean compliance with reporting items was 2, 5.2 for internal validity and 1.5 for external validity. The index test result was described in sufficient detail in 80.1% of studies and was interpreted without knowledge of the reference standard test result in only 33.1%. Loss to follow-up was adequately explained in only 31.1% of studies. The prevalence of deficiencies observed may be due to inadequate reporting but may also reflect lack of attention to methodological issues that could bias the results of diagnostic test performance estimates. QUADAS was a useful tool for assessing and comparing the quality of studies measuring the performance of diagnostic tests but might be improved further by including explicit assessment of population sampling strategy.en_US
dc.description.sponsorshipThe SE3238 project “Meta-analysis of diagnostic tests and modelling to identify appropriate testing strategies to reduce M. bovis infection in GB herds” was funded by the UK Department for Environment, Food and Rural Affairs (Defra).en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/297
dc.identifier.citationDowns, S.H., More, S.J., Goodchild, A.V., Whelan, A.O., Abernethy, D.A., Broughan, J.M., Cameron, A., Cook, A.J., Ricardo de la Rua-Domenech, R., Greiner, M., Gunn, J., Nuñez-Garcia, J., Rhodes, S., Rolfe, S., Sharp, M., Upton, P., Watson, E., Welsh, M., Woolliams, J.A., Clifton-Hadley, R.S. and Parry, J.E. (2018) ‘Evaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADAS’, Preventive Veterinary Medicine. Elsevier BV. doi:10.1016/j.prevetmed.2017.03.006.en_US
dc.identifier.issn0167-5877
dc.identifier.urihttps://doi.org/10.1016/j.prevetmed.2017.03.006
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.rightsCrown Copyright © 2017 Published by Elsevier B.V. This is an open access article under the Open Government License (OGL) (http://www.nationalarchives.gov.uk/doc/open-government-licence/ version/3/).en_US
dc.subjectBovine tuberculosisen_US
dc.subjectDiagnostic testsen_US
dc.subjectEvaluationen_US
dc.subjectExternal validityen_US
dc.subjectInternal validityen_US
dc.subjectQualityen_US
dc.titleEvaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADASen_US
dc.typeArticleen_US
dcterms.dateAccepted2017-03-18
dcterms.dateSubmitted2016-08-27

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