Smyth, Victoria J.2021-07-162021-07-162017-02-10Smyth, V. (2017) ‘A Review of the Strain Diversity and Pathogenesis of Chicken Astrovirus’, Viruses, 9(2), p. 29. doi: 10.3390/v9020029.1999-4915https://doi.org/10.3390/v9020029Publication history: Accepted - 25 January 2017; Published online - 10 February 2017.Although a relatively recently emerged virus, identified only in 2004 as a separate species of avian astrovirus, chicken astrovirus (CAstV) has been associated with poor growth of broiler flocks, enteritis and diarrhea and is a candidate pathogen in cases of runting stunting syndrome. More recently CAstV has been implicated in cases of two other diseases of broilers as the sole etiological agent, namely severe kidney disease of young broilers with visceral gout and the “White Chicks” hatchery disease. Examination of the strains of CAstV associated with the two latter diseases reveals they are closely related genetically. This review will discuss the pathogenesis of CAstV in relation to strain diversity and the effects of vertical versus horizontal transmission, virus load, co-infections and age of bird at infection, all factors that may impact upon disease severity.en© 2017 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).chicken astrovirusstrain diversitypathogenesisArticle