Butucel, EugeniaBalta, IgoriAhmadi, MirelaDumitrescu, GabiMorariu, FloricaPet, IoanStef, LaviniaCorcionivoschi, Nicolae2022-06-012022-06-012022-02-04Butucel, E., Balta, I., Ahmadi, M., Dumitrescu, G., Morariu, F., Pet, I., Stef, L. and Corcionivoschi, N. (2022) ‘Biocides as Biomedicines against Foodborne Pathogenic Bacteria’, Biomedicines. MDPI AG. doi:10.3390/biomedicines10020379.2227-9059 (electronic)https://doi.org/10.3390/biomedicines10020379Publication history: Accepted - 31 January 2022; Published - 4 February 2022.Biocides are currently considered the first line of defense against foodborne pathogens in hospitals or food processing facilities due to the versatility and efficiency of their chemical active ingredients. Understanding the biological mechanisms responsible for their increased efficiency, especially when used against foodborne pathogens on contaminated surfaces and materials, represents an essential first step in the implementation of efficient strategies for disinfection as choosing an unsuitable product can lead to antibiocide resistance or antibiotic–biocide cross-resistance. This review describes these biological mechanisms for the most common foodborne pathogens and focuses mainly on the antipathogen effect, highlighting the latest developments based on in vitro and in vivo studies. We focus on biocides with inhibitory effects against foodborne bacteria (e.g., Escherichia spp., Klebsiella spp., Staphylococcus spp., Listeria spp., Campylobacter spp.), aiming to understand their biological mechanisms of action by looking at the most recent scientific evidence in the field.en© 2022 by the authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).biocidesbiomedicinesdisinfectionantibiotic–biocide cross-resistancefoodborne pathogensArticle