The In Vitro and In Vivo Effect of Carvacrol in Preventing Campylobacter Infection, Colonization and in Improving Productivity of Chicken Broilers

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dc.contributor.authorKelly, Carmel A.
dc.contributor.authorGundogdu, Ozan
dc.contributor.authorPircalabioru, Gratiela
dc.contributor.authorCean, Ada
dc.contributor.authorScates, Pamela J.
dc.contributor.authorLinton, W. Mark R.
dc.contributor.authorPinkerton, Laurette
dc.contributor.authorMagowan, Elizabeth
dc.contributor.authorStaf, Lavinia
dc.contributor.authorSimiz, Eliza
dc.contributor.authorPet, Ioan
dc.contributor.authorStewart, Sharon
dc.contributor.authorStabler, Richard
dc.contributor.authorWren, Brendan
dc.contributor.authorDorrell, Nick
dc.contributor.authorCorcionivoschi, Nicolae
dc.date.accessioned2021-08-04T14:38:25Z
dc.date.available2021-08-04T14:38:25Z
dc.date.issued2017-06-01
dc.descriptionPublication history: Accepted - 27 February 2017; Published online - 1 June 2017.en_US
dc.description.abstractThe current trend in reducing the antibiotic usage in animal production imposes urgency in the identification of novel biocides. The essential oil carvacrol, for example, changes the morphology of the cell and acts against a variety of targets within the bacterial membranes and cytoplasm, and our in vitro results show that it reduces adhesion and invasion of chicken intestinal primary cells and also biofilm formation. A trial was conducted to evaluate the effects of dietary supplementation of carvacrol at four concentrations (0, 120, 200, and 300 mg/kg of diet) on the performance of Lactobacillus spp., Escherichia coli, Campylobacter spp., and broilers. Each of the four diets was fed to three replicates/trial of 50 chicks each from day 0 to 35. Our results show that carvacrol linearly decreased feed intake, feed conversion rates and increased body weight at all levels of supplementation. Plate count analysis showed that Campylobacter spp. was only detected at 35 days in the treatment groups compared with the control group where the colonization occurred at 21 days. The absence of Campylobacter spp. at 21 days in the treatment groups was associated with a significant increase in the relative abundance of Lactobacillus spp. Also, carvacrol was demonstrated to have a significant effect on E. coli numbers in the cecum of the treatment groups, at all supplementation levels. In conclusion, this study shows for the first time that at different concentrations, carvacrol can delay Campylobacter spp., colonization of chicken broilers, by inducing changes in gut microflora, and it demonstrates promise as an alternative to the use of antibiotics.en_US
dc.identifierhttp://hdl.handle.net/20.500.12518/333
dc.identifier.citationKelly, C., Gundogdu, O., Pircalabioru, G., Cean, A., Scates, P., Linton, M., Pinkerton, L., Magowan, E., Stef, L., Simiz, E., Pet, I., Stewart, S., Stabler, R., Wren, B., Dorrell, N. and Corcionivoschi, N. (2017) ‘The In Vitro and In Vivo Effect of Carvacrol in Preventing Campylobacter Infection, Colonization and in Improving Productivity of Chicken Broilers’, Foodborne Pathogens and Disease, 14(6), pp. 341–349. doi: 10.1089/fpd.2016.2265.en_US
dc.identifier.issn1535-3141
dc.identifier.issn1556-7125
dc.identifier.urihttps://doi.org/10.1089/fpd.2016.2265
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.rightsCopyright 2017, Mary Ann Liebert, Inc. This work is made available online in accordance with the publisher's policies. Please refer to any applicable terms of use of the publisher.en_US
dc.subjectCampylobacteren_US
dc.subjectCarvacrolen_US
dc.subjectinfectionen_US
dc.subjectcolonizationen_US
dc.subjectbiofilmen_US
dc.titleThe In Vitro and In Vivo Effect of Carvacrol in Preventing Campylobacter Infection, Colonization and in Improving Productivity of Chicken Broilersen_US
dc.typeArticleen_US
dcterms.dateAccepted2017-02-27

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